After being separated for almost two years, Arquette filed for divorce in June 2012.On June 13, 2004, she gave birth to their first child, daughter Coco Riley Arquette.Cox and her husband, David Arquette, are the executive producers of the series.
The six principal cast members, including Cox, became household names.
During her time on Friends, Cox appeared in the highly successful and high-profile Hollywood films Scream (1996), Scream 2 (1997), and Scream 3 (2000) as the ruthless reporter Gale Weathers.
Cox first came to prominence in the 1984 music video for Bruce Springsteen's "Dancing in the Dark" (in which she was the pulled-on-stage girl who danced onstage with Springsteen for 26 seconds).
Cox is also notable for being the first person to use the word "period" on U. television in its physiological sense, in a 1985 advertising campaign for Tampax brand tampons.
Since Friends, Cox has primarily concentrated on her family but has starred in the independent film November (2005), which had a limited theatrical release, co-starred with Tim Allen in the critically derided Zoom and cameoed in the big budget remake of The Longest Yard, as the girlfriend of Adam Sandler.
Cox later said her breasts were digitally enhanced to portray her role as the wife of a quarterback.
Her early film roles include Masters of the Universe (1987) and Cocoon: The Return (1988). She had a supporting role as Jewel, the hard-as-nails assistant to Jim Belushi's character in the 1990 fantasy film Mr. In 1994, Cox appeared as Meryl, Jerry's girlfriend/pretend wife on the hit TV sitcom Seinfeld.
Cox's early television work include a starring role in the short-lived television series Misfits of Science (1985), and later a recurring role (1987 - 1989) on the television series Family Ties as the last girlfriend of Alex P. After appearing in the Jim Carrey comedy Ace Ventura: Pet Detective (1994), Cox found fame playing Monica Geller on the hit TV series Friends (1994-2004).
Such films include The Runne, 3000 Miles to Graceland and The Shrink Is In.
In late 2003, Cox produced the television series Mix It Up.
She attended Mountain Brook High School, where she was a cheerleader, tennis player and swimmer.