At the age of 15 she released her debut single "Because We Want To", which made her the youngest artist to enter at number one on the UK Singles Chart.
BBC News named her one of its "Faces of the Year" for 2005, primarily due to her success in Doctor Who.
At The South Bank Show Awards in January 2006, she was awarded The Times Breakthrough Award for her successful transition from singing to acting.
From 2007 until 2011, she starred as the high-flying escort Belle de Jour in the television series Secret Diary of a Call Girl.
She also starred as Brona Croft/Lily in the Showtime series Penny Dreadful.
In the autumn of 2003, it was announced that Doctor Who would be resurrected in 2005 after a sixteen-year absence from TV; the casting of Piper as Rose Tyler, a travelling companion to the ninth incarnation of The Doctor (to be played by Christopher Eccleston), was announced in May 2004.
Piper won the Most Popular Actress category at the 20 National Television Awards for her work on Doctor Who.
Piper's debut album Honey to the B was released immediately afterwards, and debuted and peaked at number 14 in the UK album charts, selling more than 300,000 copies in the UK alone along with a platinum certification, and a 2x platinum certification in New Zealand, where it reached number three.
However, Honey to the B found limited success in other territories, such as Australia, where it debuted and peaked at number 31 despite the success of "Honey to the Bee", and in the US, it almost went completely unnoticed, peaking at number 17 on the Heatseekers.
At the 1998 Smash Hits Poll Winners' party, Piper was nominated for Best New Act (for which she came second, it being won by B*Witched) and won Princess of Pop (she was the first to win this award).
She then released "She Wants You" as the third single from the album. "Honey to the Bee" was released as the fourth single from the album; like the previous single, it reached number three.
Piper's career began when she was selected to appear on the Saturday-morning children's television show Scratchy & Co.