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The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17.

Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals.rd; rd1; Pdeb; r; rd; rd10; nmf137; r; retinal degeneration; retinal degeneration 1; retinal degeneration 10; CSNB3; CSNBAD2; rd1; rd-1; rd10; PDEB; RP40; phosphodiesterase, c GMP, rod receptor, beta polypeptide; Pdeb; GMP-PDEbeta We will fulfill your order by providing at least two carriers for each strain ordered.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

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Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

)65Dn mice provide a postnatal model for Down syndrome.

Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are orthologous to human Chr 21 genes.

Therefore, we cannot guarantee a strain's phenotype will meet all expectations.

To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON").

"PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives.

001924) trisomic mice in that they display slightly shorter body length and lower body weight), show reduced grip strength, nocturnal hyperactivity, and impaired performance in the Morris water maze.

Any differences in the Morris water maze tests for the two genetic backgrounds were found to be very subtle.

Northern and Western blotting, enzyme activity assays and reverse phase protein arrays (RPPA) demonstrate that some but not all genes in the translocation product are expressed at elevated levels in segmentally trisomic animals. 003647), and is therefore segregating for the spontaneous mutation. In 2015, researchers at The Jackson Laboratory discovered C3H/He Sn J inbred mice harbor a spontaneous, intracisternal A-particle (IAP) retrotransposon-mediated insertion in exon 2 of )65Dn (Stock No.

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