Vidya followed the success of Paa with the Vishal Bhardwaj-produced Ishqiya (2010), a black comedy directed by debutant Abhishek Chaubey; co-starring Naseeruddin Shah, Arshad Warsi, and Salman Shahid.Vidya's role was that of the sexually manipulative Krishna Verma.
Her next release was Nikhil Advani's Salaam-e-Ishq: A Tribute To Love, a romantic comedy featuring an ensemble cast, in which she was paired opposite John Abraham.
The film, which narrated six love stories, saw Vidya play the role of a television reporter, Tehzeeb Hussain, suffering from a memory loss condition.
Reviewers, while being generally negative of the film, were appreciative of Vidya's performance.
Writing for Hindustan Times, Khalid Mohamed described her as "bankably likeable" and Bollywood Hungama's Taran Adarsh labelled her as "splendid".
She initially drew criticism for her fluctuating weight and "questionable" dress sense, but was later credited in the media for "not morphing herself to fit into any conventional slot". After failing to start a film career, Vidya appeared in approximately 60 television commercials and in music videos for Euphoria and Shubha Mudgal; a majority of these were directed by Pradeep Sarkar.
The postponement of a film starring Mohanlal was an unheard occurrence in Malayalam cinema and producers blamed Vidya for bringing "bad luck" to the project; labelled her as a "jinx"; and replaced her in the films that she had been contracted for. The film, an adaptation of Sarat Chandra Chattopadhyay's novel of the same name, narrated the love story of an idealist Lalita (Vidya) and a musician Shekhar (Saif Ali Khan), the son of a capitalist businessman.Vidya's fifth and final film of 2007 was Priyadarshan's Bhool Bhulaiyaa, a remake of the Malayalam film Manichitrathazhu (1993).Vidya featured as Avani Chaturvedi (a character played by Shobana in the Malayalam original), a woman suffering from dissociative identity disorder.This changed when she starred as a radio jockey in Tumhari Sulu (2017) and a scientist in Mission Mangal (2019). In addition to acting in films, Vidya promotes humanitarian causes and supports the empowerment of women.She is also a member of the Indian Central Board of Film Certification and hosts a radio show. However, after completing the first shooting schedule, she was unceremoniously dropped and replaced by Meera Jasmine.She subsequently featured in television commercials and music videos.