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The G-spot, also called the Gräfenberg spot (for German gynecologist Ernst Gräfenberg), is characterized as an erogenous area of the vagina that, when stimulated, may lead to strong sexual arousal, powerful orgasms and potential female ejaculation.

It is typically reported to be located 5–8 cm (2–3 in) up the front (anterior) vaginal wall between the vaginal opening and the urethra and is a sensitive area that may be part of the female prostate.

The potential risks include sexual dysfunction, infection, altered sensation, dyspareunia, adhesions and scarring.

The effects of G-spot stimulation when using the penis or a G-spot vibrator may be enhanced by additionally stimulating other erogenous zones on a woman's body, such as the clitoris or vulva as a whole.

When using a G-spot vibrator, this may be done by manually stimulating the clitoris, including by using the vibrator as a clitoral vibrator, or, if the vibrator is designed for it, by applying it so that it stimulates the head of the clitoris, the rest of the vulva and the vagina simultaneously.

The research, headed by Tim Spector, documents a 15-year study of the twins, identical and non-identical.

Identical twins share genes, while non-identical pairs share 50% of theirs.

Modern scientific hypotheses linking G-spot sensitivity with female ejaculation led to the idea that non-urine female ejaculate may originate from the Skene's gland, with the Skene's gland and male prostate acting similarly in terms of prostate-specific antigen and prostate-specific acid phosphatase studies, G-spot amplification (also called G-spot augmentation or the G-Shot) is a procedure intended to temporarily increase pleasure in sexually active women with normal sexual function, focusing on increasing the size and sensitivity of the G-spot.

G-spot amplification is performed by attempting to locate the G-spot and noting measurements for future reference.On the basis of this research, they argued that women may be able to achieve vaginal orgasm via stimulation of the G-spot because the highly innervated clitoris is pulled closely to the anterior wall of the vagina when the woman is sexually aroused and during vaginal penetration.They assert that since the front wall of the vagina is inextricably linked with the internal parts of the clitoris, stimulating the vagina without activating the clitoris may be next to impossible.In a 1990 study, an anonymous questionnaire was distributed to 2,350 professional women in the United States and Canada with a subsequent 55% return rate.Of these respondents, 40% reported having a fluid release (ejaculation) at the moment of orgasm, and 82% of the women who reported the sensitive area (Gräfenberg spot) also reported ejaculation with their orgasms.While using MRI technology, O'Connell noted a direct relationship between the legs or roots of the clitoris and the erectile tissue of the "clitoral bulbs" and corpora, and the distal urethra and vagina.

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